Overview

  • Product name
  • Description
    Goat polyclonal to ABCC11
  • Specificity
    This antibody is expected to recognize both reported isoforms (NP_115972.2; NP_660187.1).
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide: C-

    KVVEFDRPEVLRK

    from the internal region (near the C terminus) of the human ABCC11 protein sequence according to NP_115972.2; NP_660187.1.

  • Positive control
    • Human breast and human testis lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab82152 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: Antibody detection limit dilution 1/32,000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 154 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      ABCC11 belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily. It contains two ABC transmembrane type-1 domains and two ABC transporter domains. ABCC11 participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides and enhances the cellular extrusion of cAMP and cGMP. It also stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. It probably functions to secrete earwax.
    • Cellular localization
      Membrane; Multi-pass membrane protein.
    • Database links
    • Alternative names
      • ABCC 11 antibody
      • ATP binding cassette protein C11 antibody
      • ATP binding cassette sub family C (CFTR/MRP) member 11 antibody
      • ATP binding cassette sub family C member 11 antibody
      • ATP binding cassette transporter MRP8 antibody
      • ATP binding cassette transporter sub family C member 11 antibody
      • EWWD antibody
      • MRP8 antibody
      • Multi resistance protein 8 antibody
      • Multidrug resistance associated protein 8 antibody
      • OTTHUMP00000164191 antibody
      • WW antibody
      see all

    Images

    • Anti-ABCC11 antibody (ab82152) at 0.5 µg/ml + human breast lysate in RIPA buffer at 35 µg
      Developed using the ECL technique

      Predicted band size : 154 kDa
      Observed band size : 125 kDa (why is the actual band size different from the predicted?)


      Exposure time : 1 hour

    References

    ab82152 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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