Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab91452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

Acetone fixed cytospin preparations.

ab37371 - Rat polyclonal IgG, is suitable for use as an isotype control with this antibody. 

WB 1/20 - 1/50. Predicted molecular weight: 154 kDa.
IHC-Fr 1/20.
ICC 1/20 - 1/50.

Target

  • Relevance
    ABCC11 belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily. It contains two ABC transmembrane type-1 domains and two ABC transporter domains. ABCC11 participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides and enhances the cellular extrusion of cAMP and cGMP. It also stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. It probably functions to secrete earwax.
  • Cellular localization
    Membrane; Multi-pass membrane protein.
  • Database links
  • Alternative names
    • ABCC 11 antibody
    • ATP binding cassette protein C11 antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 11 antibody
    • ATP binding cassette sub family C member 11 antibody
    • ATP binding cassette transporter MRP8 antibody
    • ATP binding cassette transporter sub family C member 11 antibody
    • EWWD antibody
    • MRP8 antibody
    • Multi resistance protein 8 antibody
    • Multidrug resistance associated protein 8 antibody
    • OTTHUMP00000164191 antibody
    • WW antibody
    see all

Images

  • ab91452 at 1/50 dilution staining ABCC11 in ABCC11 transfected human HEK cells by Immunocytochemistry. Image show positive staining of non-transfected and ABCC11 transfected HEK cells.

References

This product has been referenced in:
  • Toyoda Y  et al. Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis. Int J Mol Sci 18:N/A (2017). Read more (PubMed: 28212277) »

See 1 Publication for this product

Customer reviews and Q&As

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The antibody ab91452 has been tested in WB, IHC with frozen sections, flow cytometry as well as immunocytochemistry (i.e. with cultured cells). Therefore, the antibody is guaranteed for these tested applications ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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