The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
1/2500. Detects a band of approximately 90 kDa (predicted molecular weight: 76 kDa).
FunctionTransporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
Tissue specificityExpressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus membrane. Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
ab36969 staining ABCG1 in lung and alveolar macrophages by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
References for Anti-ABCG1 antibody (ab36969)
This product has been referenced in:
Voloshyna I et al. Infliximab reverses suppression of cholesterol efflux proteins by TNF-a: a possible mechanism for modulation of atherogenesis. Biomed Res Int2014:312647 (2014).
Read more (PubMed: 24587984) »
Zhao J et al. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. J Biol Chem289:11282-92 (2014).
Read more (PubMed: 24599963) »