WB: Preliminary experiments in human brain (cerebellum, frontal cortex, hippocampus) and in mouse mye and rat retina lysates gave no specific signal but low background (at antibody concentration up to 1 µg/ml). We would appreciate your feedback if you have tested this antibody in more suitable positive controls.
RelevanceThe ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts for numerous proteins involved in trafficking of biological molecules across membranes. ABCG4 protein is highly expressed in both human and mouse brain, it is a 646aa molecule in human (chr 11q23) and mouse. It is an integral membrane protein may be involved in macrophage lipid homeostasis. The ABCG4 protein’s abundant expression in brain and close evolutionary relationship to the other members of the subfamily suggests a potential role in cholesterol transport.
Cellular localizationMembrane; Multi-pass membrane protein