FunctionMay act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Sequence similaritiesBelongs to the ABI family. Contains 1 SH3 domain. Contains 1 t-SNARE coiled-coil homology domain.
Post-translational modificationsIs a substrate for ABL1.
Cellular localizationCytoplasm and Cell projection > lamellipodium. Cell projection > filopodium. Cytoplasm > cytoskeleton. Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips.
Abl interacting protein 1 (SH3 containing protein) antibody
Abl interactor 2 antibody
Abl interactor protein 2b antibody
Abl-binding protein 3 antibody
AIP 1 antibody
Arg binding protein 1 antibody
Arg protein tyrosine kinase binding protein antibody
Arg-binding protein 1 antibody
Anti-ABI2 antibody images
Western blot - ABI2 antibody (ab113991)
All lanes : Anti-ABI2 antibody (ab113991) at 0.4 µg/ml
Lane 1 : HeLa whole cell lysate at 50 µg Lane 2 : HeLa whole cell lysate at 15 µg Lane 3 : HeLa whole cell lysate at 5 µg
Developed using the ECL technique
Predicted band size : 56 kDa
Exposure time : 30 seconds
Immunoprecipitation - ABI2 antibody (ab113991)
ab113991, at 1 µg/ml, detecting ABI2 by WB following immunoprecipitation. Lane 1: IP using a rabbit anti-ABI2 which recognizes an upstream epitope Lane 2: IP using ab113991 Lane 3; IP using control IgG.
ab113991 was used for immunoprecipitation at 3 µg/mg of HeLa whole cell lysate. 1 mg of lysate was used for IP and 20% of IP was loaded. Detection: Chemiluminescence with a 3 minute exposure time.
References for Anti-ABI2 antibody (ab113991)
has not yet been referenced specifically in any publications.
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