Overview

  • Product name
  • Description
    Rabbit polyclonal to ACAD8
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 125-154 of Human ACAD8 (UniProt ID: Q9UKU7) conjugated to KLH.

  • Positive control
    • Mouse stomach tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab102810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 45 kDa.

Target

  • Function
    Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.
  • Tissue specificity
    Detected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney.
  • Pathway
    Amino-acid degradation; L-valine degradation.
  • Involvement in disease
    Defects in ACAD8 are the cause of isobutyryl-CoA dehydrogenase deficiency (IBDD) [MIM:611283]. The symptoms of IBDD generally appear until late in infancy or in childhood and can include poor feeding and growth (failure to thrive), a weakened and enlarged heart (dilated cardiomyopathy), seizures, and low numbers of red blood cells (anemia).
  • Sequence similarities
    Belongs to the acyl-CoA dehydrogenase family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACAD 8 antibody
    • ACAD-8 antibody
    • ACAD8 antibody
    • ACAD8_HUMAN antibody
    • Activator-recruited cofactor 42 kDa component antibody
    • Acyl CoA dehydrogenase family member 8 antibody
    • Acyl Coenzyme A dehydrogenase family member 8 antibody
    • Acyl-CoA dehydrogenase family member 8 antibody
    • ARC42 antibody
    • FLJ22590 antibody
    • IBD antibody
    • Isobutyryl-CoA dehydrogenase antibody
    • Isobutyryl-CoA dehydrogenase, mitochondrial antibody
    • mitochondrial antibody
    see all

Images

  • Anti-ACAD8 antibody (ab102810) at 1/100 dilution + Mouse stomach tissue lysates at 35 µg

    Predicted band size : 45 kDa

References

ab102810 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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