Overview

  • Product nameAnti-ACADSB antibody
    See all ACADSB primary antibodies
  • Description
    Rabbit polyclonal to ACADSB
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to internal sequence amino acids 180-402 of Human ACADSB (BC013756).

  • Positive control
    • Human fetal liver cell lysate, human fetal colon tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab99951 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 47 kDa.
IHC-P 1/100 - 1/500.

Target

  • FunctionHas greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.
  • Tissue specificityUbiquitous.
  • PathwayLipid metabolism; mitochondrial fatty acid beta-oxidation.
  • Involvement in diseaseDefects in ACADSB are the cause of short/branched-chain acyl-CoA dehydrogenase deficiency (SBCADD) [MIM:610006]; also known as 2-methylbutyryl-CoA dehydrogenase deficiency or 2-methylbutyryl glycinuria. SBCADD is an autosomal recessive disorder and consists of a defect in catabolism of L-isoleucine which is characterized by an increase of 2-methylbutyrylglycine and 2-methylbutyrylcarnitine in blood and urine. Affected individuals have seizures and psychomotor delay as the main clinical features.
  • Sequence similaritiesBelongs to the acyl-CoA dehydrogenase family.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 MEBCAD antibody
    • 2 methyl branched chain acyl CoA dehydrogenase antibody
    • 2 methylbutyryl CoA dehydrogenase antibody
    • 2 methylbutyryl coenzyme A dehydrogenase antibody
    • 2-MEBCAD antibody
    • 2-methyl branched chain acyl-CoA dehydrogenase antibody
    • 2-methylbutyryl-CoA dehydrogenase antibody
    • 2-methylbutyryl-coenzyme A dehydrogenase antibody
    • ACAD7 antibody
    • ACADSB antibody
    • ACDSB_HUMAN antibody
    • acyl CoA dehydrogenase, short/branched chain antibody
    • acyl Coenzyme A dehydrogenase short branched chain antibody
    • mitochondrial antibody
    • OTTHUMP00000020685 antibody
    • OTTHUMP00000046795 antibody
    • SBCAD antibody
    • Short/branched chain specific acyl-CoA dehydrogenase antibody
    • short/branched chain specific acyl-CoA dehydrogenase, mitochondrial antibody
    see all

Anti-ACADSB antibody images

  • Anti-ACADSB antibody (ab99951) at 1/500 dilution + Human fetal liver lysate

    Predicted band size : 47 kDa
  • ab99951, at 1/100 dilution, staining ACADSB in human fetal colon.

References for Anti-ACADSB antibody (ab99951)

ab99951 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"