Overview

  • Product name
    Anti-ACCN1 antibody [EPR11029]
    See all ACCN1 primary antibodies
  • Description
    Rabbit monoclonal [EPR11029] to ACCN1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to residues in Human ACCN1 (UniProt: Q16515).

  • Positive control
    • Human fetal kidney and Human glioma lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    Preservative: 0.01% Sodium azide
    Constituents: 50% Glycerol, 0.05% BSA
  • Purity
    Tissue culture supernatant
  • Clonality
    Monoclonal
  • Clone number
    EPR11029
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab169768 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 58 kDa.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function
      Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
    • Tissue specificity
      Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
    • Sequence similarities
      Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN1 subfamily.
    • Cellular localization
      Cell membrane. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
    • Information by UniProt
    • Database links
    • Alternative names
      • ACCN antibody
      • ACCN1 antibody
      • ACCN1_HUMAN antibody
      • Acid sensing ion channel 2 antibody
      • Acid-sensing ion channel 2 antibody
      • Amiloride sensitive brain sodium channel antibody
      • Amiloride sensitive cation channel 1 neuronal (degenerin) antibody
      • Amiloride sensitive cation channel 1 neuronal antibody
      • Amiloride-sensitive brain sodium channel antibody
      • Amiloride-sensitive cation channel 1, neuronal antibody
      • Amiloride-sensitive cation channel neuronal 1 antibody
      • ASIC2 antibody
      • ASIC2a antibody
      • BNaC1 antibody
      • BNC1 antibody
      • Brain sodium channel 1 antibody
      • Degenerin antibody
      • hBNaC1 antibody
      • Mammalian degenerin homolog antibody
      • MDEG antibody
      • Neuronal amiloride sensitive cation channel 1 antibody
      see all

    Images

    • All lanes : Anti-ACCN1 antibody [EPR11029] (ab169768) at 1/1000 dilution

      Lane 1 : Human fetal kidney lysate
      Lane 2 : Human glioma lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labeled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 58 kDa

    References

    This product has been referenced in:
    • Zhang H  et al. Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy. Sci Rep 7:5870 (2017). Read more (PubMed: 28725010) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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