Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN1 subfamily.
Cell membrane. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.