Acetyl Coenzyme A Carboxylase peptide (ab195232)

Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab195232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Acetyl Coenzyme A Carboxylase antibody [EP687Y] (ab45174)

  • Form
    Liquid
  • Additional notes

    This is the blocking peptide for ab45174

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names
    • ACAC
    • ACACA
    • ACACA_HUMAN
    • ACACB
    • ACC
    • ACC alpha
    • ACC beta
    • ACC-alpha
    • ACC1
    • ACC2
    • ACCA
    • ACCB
    • Acetyl CoA carboxylase 1
    • Acetyl CoA carboxylase 2
    • Acetyl CoA carboxylase alpha
    • Acetyl CoA carboxylase beta
    • Acetyl Coenzyme A carboxylase alpha
    • Acetyl Coenzyme A carboxylase beta
    • Biotin carboxylase
    • COA1
    • COA2
    • HACC275
    • OTTHUMP00000164069
    • OTTHUMP00000164070
    • OTTHUMP00000164076
    • OTTHUMP00000240532
    see all
  • Function
    Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
  • Tissue specificity
    Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
  • Pathway
    Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
  • Involvement in disease
    Acetyl-CoA carboxylase 1 deficiency
  • Sequence similarities
    Contains 1 ATP-grasp domain.
    Contains 1 biotin carboxylation domain.
    Contains 1 biotinyl-binding domain.
    Contains 1 carboxyltransferase domain.
  • Post-translational
    modifications
    Phosphorylation on Ser-1263 is required for interaction with BRCA1.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab195232 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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