Acetyl Coenzyme A Carboxylase peptide (ab204881)

Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Sequence
      HMRSAMSGLHLVKRR

Specifications

Our Abpromise guarantee covers the use of ab204881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    HPLC

  • Form
    Lyophilised
  • Additional notes

    ab204881 (Acetyl Coenzyme A Carboxylase peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab184883 (Active human AMPK alpha 1 + AMPK beta 2 +AMPK gamma 2 full length protein)
    ab79803 (Active human AMPK alpha1 + AMPK beta1 + AMPK gamma1 full length protein)
    ab126911 (Active human PRKAA2 + PRKAB2 + PRKAG1 full length protein)
    ab126916 (Active human AMPK alpha 2 full length protein)
    ab184885 (Active human AMPK alpha 1 + AMPK beta 2 + AMPK gamma 3 full length protein)
    ab185258 (Active human AMPK alpha 2 + beta 1 + gamma 2 full length protein)

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

General Info

  • Alternative names
    • ACAC
    • ACACA
    • ACACA_HUMAN
    • ACACB
    • ACC
    • ACC alpha
    • ACC beta
    • ACC-alpha
    • ACC1
    • ACC2
    • ACCA
    • ACCB
    • Acetyl CoA carboxylase 1
    • Acetyl CoA carboxylase 2
    • Acetyl CoA carboxylase alpha
    • Acetyl CoA carboxylase beta
    • Acetyl Coenzyme A carboxylase alpha
    • Acetyl Coenzyme A carboxylase beta
    • Biotin carboxylase
    • COA1
    • COA2
    • HACC275
    • OTTHUMP00000164069
    • OTTHUMP00000164070
    • OTTHUMP00000164076
    • OTTHUMP00000240532
    see all
  • Function
    Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
  • Tissue specificity
    Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
  • Pathway
    Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
  • Involvement in disease
    Acetyl-CoA carboxylase 1 deficiency
  • Sequence similarities
    Contains 1 ATP-grasp domain.
    Contains 1 biotin carboxylation domain.
    Contains 1 biotinyl-binding domain.
    Contains 1 carboxyltransferase domain.
  • Post-translational
    modifications
    Phosphorylation on Ser-1263 is required for interaction with BRCA1.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab204881 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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