For the best experience on the Abcam website please upgrade to a modern browser such as
Rabbit polyclonal to Acetyl Coenzyme A Carboxylase (phospho S80)
The antibody detects endogenous levels of Human Acetyl Coenzyme A Carboxylase only when phosphorylated at serine 80 (Serine 79 in Mouse and Rat).
Predicted to work with:
Synthetic phosphopeptide derived from human Acetyl Coenzyme A Carboxylase around the phosphorylation site of serine 80 (S-M-S
Human skeletal muscle tissue.
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg 2+ and Ca 2+), 150mM Sodium chloride, pH 7.4
Concentration information loading...
Immunogen affinity purified
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Involvement in disease
Acetyl-CoA carboxylase 1 deficiency
Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain. Contains 1 biotinyl-binding domain. Contains 1 carboxyltransferase domain.
Phosphorylation on Ser-1263 is required for interaction with BRCA1.
Information by UniProt
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"