Anti-Acid Phosphatase 2 antibody (ab113844)

Overview

  • Product name
    Anti-Acid Phosphatase 2 antibody
    See all Acid Phosphatase 2 primary antibodies
  • Description
    Rabbit polyclonal to Acid Phosphatase 2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Human, Pig, Macaque monkey, Rhesus monkey, Orangutan
  • Immunogen

    Synthetic peptide: GQALRQRYHG FLNASYHRQE VYVRSTDFDR TLMSAEANLA GLFPPTEVQH , corresponding to a region within the internal sequence amino acids 80-129 of Human Acid Phosphatase 2 (NP_058684).

  • Positive control
    • Rat kidney lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab113844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Involvement in disease
    Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD) [MIM:200950]. The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues.
  • Sequence similarities
    Belongs to the histidine acid phosphatase family.
  • Post-translational
    modifications
    The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
    N-glycosylated. The intermediates formed during enzymatic deglycosylation suggest that all eight predicted N-glycosylation sites are used.
  • Cellular localization
    Lysosome membrane. Lysosome lumen. The soluble form arises by proteolytic processing of the membrane-bound form.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acid phosphatase 2 lysosomal antibody
    • ACP 2 antibody
    • ACP2 antibody
    • LAP antibody
    • Lysosomal acid phosphatase 2 antibody
    • Lysosomal acid phosphatase antibody
    • PPAL_HUMAN antibody
    see all

Images

  • Anti-Acid Phosphatase 2 antibody (ab113844) at 1 µg/ml + Rat Kidney lysate at 10 µg

    Predicted band size : 48 kDa

References

ab113844 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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