Overview

  • Product name
    Anti-Acid Phosphatase 2 antibody
    See all Acid Phosphatase 2 primary antibodies
  • Description
    Goat polyclonal to Acid Phosphatase 2
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog, Cynomolgus monkey, Orangutan
  • Immunogen

    Synthetic peptide:

    C-QNETRQTPEYQN

    , corresponding to internal sequence amino acids 166-177 of Human Acid Phosphatase 2

  • Positive control
    • Human prostate tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab85719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/16000.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Involvement in disease
    Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD) [MIM:200950]. The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues.
  • Sequence similarities
    Belongs to the histidine acid phosphatase family.
  • Post-translational
    modifications
    The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
    N-glycosylated. The intermediates formed during enzymatic deglycosylation suggest that all eight predicted N-glycosylation sites are used.
  • Cellular localization
    Lysosome membrane. Lysosome lumen. The soluble form arises by proteolytic processing of the membrane-bound form.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acid phosphatase 2 lysosomal antibody
    • ACP 2 antibody
    • ACP2 antibody
    • LAP antibody
    • Lysosomal acid phosphatase 2 antibody
    • Lysosomal acid phosphatase antibody
    • PPAL_HUMAN antibody
    see all

Images

  • ab85719, at 5µg/ml, staining Acid Phosphatase 2 in formalin-fixed, paraffin-embedded Human prostate tissue by Immunohistochemistry.

References

ab85719 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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