Overview

  • Product nameAnti-Acinus antibody
    See all Acinus primary antibodies
  • Description
    Rabbit polyclonal to Acinus
  • SpecificityRecognizes Acinus L, Acinus S and Acinus S'.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    6HIS fusion protein, corresponding to amino acids 1233-1341 of Human Acinus.

  • Positive control
    • Jurkat lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab18519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 0.5 - 1 µg/ml. Detects Acinus L, Acinus S and Acinus S' at 220, 98 and 94 kDa respectively, in RIPA lysates from Jurkat cells. Detection of Acinus L was lost in Jurkat cells treated with 0.5 µM staurosporin for 6 hours. Loss of Acinus L is observed upon induction of apoptosis.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
    • Tissue specificityUbiquitous.
    • Sequence similaritiesContains 1 SAP domain.
    • Post-translational
      modifications
      Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • ACIN 1 antibody
      • ACIN1 antibody
      • ACINU_HUMAN antibody
      • Acinus antibody
      • ACN antibody
      • Apoptotic chromatin condensation inducer 1 antibody
      • Apoptotic chromatin condensation inducer in the nucleus antibody
      • DKFZp667N107 antibody
      • fSAP152 antibody
      • functional spliceosome-associated protein 152 antibody
      • KIAA0670 antibody
      see all

    References for Anti-Acinus antibody (ab18519)

    ab18519 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"