Overview

  • Product nameAnti-Acinus antibody
    See all Acinus primary antibodies
  • Description
    Rabbit polyclonal to Acinus
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region between residue 1291 and the C-terminus (residue 1341) of human Acinus (NP_055792.1)

  • Positive control
    • human basal cell carcinoma and human stomach adenocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab84454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • FunctionComponent of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesContains 1 SAP domain.
  • Post-translational
    modifications
    Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACIN 1 antibody
    • ACIN1 antibody
    • ACINU_HUMAN antibody
    • Acinus antibody
    • ACN antibody
    • Apoptotic chromatin condensation inducer 1 antibody
    • Apoptotic chromatin condensation inducer in the nucleus antibody
    • DKFZp667N107 antibody
    • fSAP152 antibody
    • functional spliceosome-associated protein 152 antibody
    • KIAA0670 antibody
    see all

Anti-Acinus antibody images

  • ab84454, at 1/250 dilution, staining Acinus in formalin-fixed, paraffin-embedded stomach adenocarcinoma. by Immunohistochemistry, using DAB detection.
  • ab84454, at 1/250 dilution, staining Acinus in formalin-fixed, paraffin-embedded human basal cell carcinoma. by Immunohistochemistry, using DAB detection.

References for Anti-Acinus antibody (ab84454)

This product has been referenced in:
  • Singh SS  et al. Comparison of ACINUS, caspase-3, and TUNEL as apoptotic markers in determination of tumor growth rates of clinically localized prostate cancer using image analysis. Prostate 69:1603-10 (2009). IHC-P ; Human . Read more (PubMed: 19644955) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"