The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500.
FunctionComponent of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
Sequence similaritiesContains 1 SAP domain.
Post-translational modificationsUndergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
ab84454, at 1/250 dilution, staining Acinus in formalin-fixed, paraffin-embedded human basal cell carcinoma. by Immunohistochemistry, using DAB detection.
References for Anti-Acinus antibody (ab84454)
This product has been referenced in:
Singh SS et al. Comparison of ACINUS, caspase-3, and TUNEL as apoptotic markers in determination of tumor growth rates of clinically localized prostate cancer using image analysis. Prostate69:1603-10 (2009).
Read more (PubMed: 19644955) »