Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab8368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • ACIN 1
    • ACIN1
    • ACINU_HUMAN
    • Acinus
    • ACN
    • Apoptotic chromatin condensation inducer 1
    • Apoptotic chromatin condensation inducer in the nucleus
    • DKFZp667N107
    • fSAP152
    • functional spliceosome-associated protein 152
    • KIAA0670
    see all
  • Function
    Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 SAP domain.
  • Post-translational
    modifications
    Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab8368 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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