Overview

  • Product nameAnti-Aconitase 1 antibody
    See all Aconitase 1 primary antibodies
  • Description
    Mouse monoclonal to Aconitase 1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 780-890 of Human Aconitase 1

Properties

Applications

Our Abpromise guarantee covers the use of ab54718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionIron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
      Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
    • Sequence similaritiesBelongs to the aconitase/IPM isomerase family.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • ACO 1 antibody
      • ACO1 antibody
      • ACOC_HUMAN antibody
      • Aconitase 1 soluble antibody
      • Aconitase antibody
      • Aconitase1 antibody
      • Aconitate hydratase antibody
      • ACONS antibody
      • Citrate hydro lyase antibody
      • Citrate hydro-lyase antibody
      • Cytoplasmic aconitate hydratase antibody
      • Ferritin repressor protein antibody
      • IRE BP 1 antibody
      • IRE-BP 1 antibody
      • IREB 1 antibody
      • IREB1 antibody
      • IREBP antibody
      • IREBP1 antibody
      • Iron regulatory protein 1 antibody
      • Iron responsive element binding protein 1 antibody
      • Iron-responsive element-binding protein 1 antibody
      • IRP 1 antibody
      • IRP1 antibody
      • OTTHUMP00000045233 antibody
      see all

    Anti-Aconitase 1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab54718 Aconitase 1 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    References for Anti-Aconitase 1 antibody (ab54718)

    This product has been referenced in:
    • Haro KJ  et al. Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells. PLoS One 7:e48841 (2012). WB ; Human . Read more (PubMed: 23155415) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab54718.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"