Anti-ACOT7 antibody (ab85151)
Key features and details
- Rabbit polyclonal to ACOT7
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ACOT7 antibody
See all ACOT7 primary antibodies -
Description
Rabbit polyclonal to ACOT7 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
A synthetic peptide from near the C terminal residues of human ACOT7 (NM_181864).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute in 200ul sterile H2O. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 2% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab85151 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/200 - 1/1000. Predicted molecular weight: 42 kDa.
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IHC-P |
1/50 - 1/200.
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Notes |
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WB
1/200 - 1/1000. Predicted molecular weight: 42 kDa. |
IHC-P
1/50 - 1/200. |
Target
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Function
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. -
Tissue specificity
Isoform 4 is expressed exclusively in brain. -
Sequence similarities
Contains 2 acyl coenzyme A hydrolase domains. -
Cellular localization
Cytoplasm and Mitochondrion. - Information by UniProt
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Database links
- Entrez Gene: 11332 Human
- Entrez Gene: 70025 Mouse
- Entrez Gene: 26759 Rat
- Omim: 602587 Human
- SwissProt: O00154 Human
- SwissProt: Q91V12 Mouse
- SwissProt: Q64559 Rat
- Unigene: 126137 Human
see all -
Alternative names
- ACH1 antibody
- ACOT 7 antibody
- ACOT7 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab85151 has been referenced in 3 publications.
- Jung SH et al. Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway. Cell Death Dis 8:e2793 (2017). WB ; Human . PubMed: 28518146
- Wall VZ et al. Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (=C20)-acyl chains in macrophages. J Lipid Res 58:1174-1185 (2017). PubMed: 28416579
- Montoya V et al. Novel miRNA-31 and miRNA-200a-Mediated Regulation of Retinoblastoma Proliferation. PLoS One 10:e0138366 (2015). WB, IF, IHC . PubMed: 26379276