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ab8925 has been referenced in 116 publications.

  • Li C  et al. CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer. Theranostics 7:67-80 (2017). PubMed: 28042317
  • Lähdeniemi IAK  et al. Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death Differ 24:984-996 (2017). IHC ; Mouse, Human . PubMed: 28475172
  • Semerci F  et al. Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance. Elife 6:N/A (2017). PubMed: 28699891
  • Di Tullio A  et al. Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation. Stem Cell Reports 9:5-11 (2017). WB, ICC/IF ; Human . PubMed: 28648895
  • Ciria M  et al. Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1a Upstream of Notch and SUMO Pathways. Stem Cells Dev 26:973-985 (2017). ICC/IF ; Human . PubMed: 28520516
  • Davis RB  et al. Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation. JCI Insight 2:e92465 (2017). PubMed: 28352669
  • Wang C  et al. IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. Nat Commun 8:15508 (2017). PubMed: 28561022
  • Miller SR  et al. Constitutively active Notch1 converts cranial neural crest-derived frontonasal mesenchyme to perivascular cells in vivo. Biol Open 6:317-325 (2017). PubMed: 28183698
  • Na J  et al. JMJD3 and NF-?B-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing. Sci Rep 7:6494 (2017). PubMed: 28747631
  • Boareto M  et al. Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype. J R Soc Interface 13:N/A (2016). IHC . PubMed: 27170649
  • Santio NM  et al. Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. Oncotarget 7:43220-43238 (2016). PubMed: 27281612
  • Tian Y  et al. Cross-talk of SFRP4, integrin a1ß1, and Notch1 inhibits cardiac differentiation of P19CL6 cells. Cell Signal 28:1806-15 (2016). PubMed: 27542621
  • Sucre JM  et al. A three-dimensional human model of the fibroblast activation that accompanies bronchopulmonary dysplasia identifies Notch-mediated pathophysiology. Am J Physiol Lung Cell Mol Physiol 310:L889-98 (2016). PubMed: 26968771
  • Upadhyay P  et al. Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer. Oncotarget 7:50437-50449 (2016). WB, IHC . PubMed: 27391340
  • Liu Y  et al. KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway. Oncotarget 7:53153-53164 (2016). PubMed: 27449290
  • Liu B  et al. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Sci Rep 6:21534 (2016). PubMed: 26867947
  • Li Z  et al. Epidermal Notch1 recruits ROR?(+) group 3 innate lymphoid cells to orchestrate normal skin repair. Nat Commun 7:11394 (2016). WB . PubMed: 27099134
  • Bi P  et al. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med 213:2019-37 (2016). WB, IHC ; Mouse, Human . PubMed: 27573812
  • Miller SR  et al. Evidence for a Notch1-mediated transition during olfactory ensheathing cell development. J Anat 229:369-83 (2016). IHC ; Chicken . PubMed: 27271278
  • Del Debbio CB  et al. Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1. PLoS One 11:e0152025 (2016). WB, ICC/IF ; Rat . PubMed: 27011052
  • Wu X  et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun 7:10533 (2016). WB, IHC (PFA fixed), ICC/IF ; Mouse, Human . PubMed: 26837467
  • Zhang S  et al. Protective effect of melatonin on soluble Aß1-42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus. Alzheimers Res Ther 8:40 (2016). IHC (PFA fixed) ; Rat . PubMed: 27630117
  • Zhong Y  et al. NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells. Onco Targets Ther 9:6865-6871 (2016). IHC-P ; Human . PubMed: 27853380
  • Li F  et al. Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway. Am J Transl Res 8:4791-4801 (2016). WB ; Rat . PubMed: 27904680
  • Shao H  et al. Notch1-WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis. Oncotarget 7:79262-79273 (2016). WB ; Mouse . PubMed: 27813493
  • Nishio M  et al. Dysregulated YAP1/TAZ and TGF-ß signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A 113:E71-80 (2016). WB ; Mouse . PubMed: 26699479
  • Dou GR  et al. Myeloid-Specific Blockade of Notch Signaling Attenuates Choroidal Neovascularization through Compromised Macrophage Infiltration and Polarization in Mice. Sci Rep 6:28617 (2016). IHC-FoFr ; Mouse . PubMed: 27339903
  • Jung ME  et al. The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal. J Pharmacol Exp Ther 358:516-26 (2016). PubMed: 27278235
  • Morimoto M  et al. Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia? Orphanet J Rare Dis 11:149 (2016). ICC/IF . PubMed: 27816064
  • López-Arribillaga E  et al. Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch. Development 142:41-50 (2015). ChIP . PubMed: 25480918
  • Shao H  et al. Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion. PLoS One 10:e0142815 (2015). PubMed: 26562315
  • Sivarapatna A  et al. Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor. Biomaterials 53:621-33 (2015). WB ; Human . PubMed: 25890758
  • Dong X  et al. Aspartate ß-Hydroxylase expression promotes a malignant pancreatic cellular phenotype. Oncotarget 6:1231-48 (2015). WB . PubMed: 25483102
  • Marsolier J  et al. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature 520:378-82 (2015). WB . PubMed: 25624101
  • Zhang JJ  et al. Bevacizumab modulates retinal pigment epithelial-to-mesenchymal transition via regulating Notch signaling. Int J Ophthalmol 8:245-9 (2015). PubMed: 25938035
  • Kim B  et al. Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy. BMC Cancer 15:634 (2015). IHC . PubMed: 26362310
  • Vaughan AE  et al. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature 517:621-5 (2015). IF . PubMed: 25533958
  • Hill-Felberg S  et al. Notch receptor expression in human brain arteriovenous malformations. J Cell Mol Med 19:1986-93 (2015). WB . PubMed: 25846406
  • Zheng KL  et al. Alternative splicing of NUMB, APP and VEGFA as the features of pancreatic ductal carcinoma. Int J Clin Exp Pathol 8:6181-91 (2015). PubMed: 26261495
  • Lan L  et al. Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. Mol Oncol 9:1406-20 (2015). PubMed: 25933687
  • Pardo-Saganta A  et al. Parent stem cells can serve as niches for their daughter cells. Nature 523:597-601 (2015). IF, IHC ; Mouse . PubMed: 26147083
  • Hayashi Y  et al. NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells. Oncol Rep 34:1650-8 (2015). IHC . PubMed: 26252838
  • Mizuno S  et al. A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool. J Biol Chem 290:28456-64 (2015). PubMed: 26453297
  • LeComte MD  et al. Notch1-STAT3-ETBR signaling axis controls reactive astrocyte proliferation after brain injury. Proc Natl Acad Sci U S A 112:8726-31 (2015). PubMed: 26124113
  • Ronchi CL  et al. Notch1 pathway in adrenocortical carcinomas: correlations with clinical outcome. Endocr Relat Cancer 22:531-43 (2015). PubMed: 25979380
  • Zhao D  et al. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest 124:5453-65 (2014). PubMed: 25384215
  • Bi P  et al. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med 20:911-8 (2014). WB . PubMed: 25038826
  • Pekkonen P  et al. KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo. Cell Cycle 13:3670-84 (2014). PubMed: 25483078
  • Martz CA  et al. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal 7:ra121 (2014). PubMed: 25538079
  • Singh A  et al. GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation. Cell Cycle 13:157-66 (2014). PubMed: 24200971
  • Li W  et al. Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells. Gastroenterology 146:1714-26.e5 (2014). WB ; Human . PubMed: 24631494
  • Rognoni E  et al. Kindlin-1 controls Wnt and TGF-ß availability to regulate cutaneous stem cell proliferation. Nat Med 20:350-9 (2014). IHC . PubMed: 24681597
  • Ottone C  et al. Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells. Nat Cell Biol 16:1045-56 (2014). IHC . PubMed: 25283993
  • Redmond EM  et al. Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling. PLoS One 9:e84122 (2014). ICC/IF ; Mouse . PubMed: 24416200
  • Lu R  et al. Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice. PLoS One 9:e93864 (2014). WB, IHC . PubMed: 24705625
  • Liu YP  et al. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J Clin Invest 124:2059-70 (2014). WB . PubMed: 24691443
  • Kanatsu-Shinohara M  et al. Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal. Proc Natl Acad Sci U S A 111:8826-31 (2014). WB ; Mouse . PubMed: 24879440
  • Tripathi R  et al. Clinical impact of de-regulated Notch-1 and Notch-3 in the development and progression of HPV-associated different histological subtypes of precancerous and cancerous lesions of human uterine cervix. PLoS One 9:e98642 (2014). IHC-P ; Human . PubMed: 24905589
  • Hirata N  et al. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat Commun 5:4806 (2014). PubMed: 25254944
  • Melo RC  et al. Pre-embedding immunogold labeling to optimize protein localization at subcellular compartments and membrane microdomains of leukocytes. Nat Protoc 9:2382-94 (2014). PubMed: 25211515
  • Cheng J  et al. Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model. J Am Heart Assoc 3:e001064 (2014). IHC-P ; Mouse . PubMed: 25349182
  • Cao YW  et al. Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer. J Exp Clin Cancer Res 33:97 (2014). IHC ; Human . PubMed: 25420528
  • Davis H  et al. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. Gut N/A:N/A (2013). WB ; Mouse . PubMed: 23676439
  • Sancho R  et al. Fbw7 repression by hes5 creates a feedback loop that modulates notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol 11:e1001586 (2013). WB ; Mouse . PubMed: 23776410
  • Li H  et al. Expression and function of NUMB in odontogenesis. Biomed Res Int 2013:182965 (2013). ICC/IF ; Mouse, Human . PubMed: 23841055
  • MacKenzie MG  et al. Inhibition of myostatin signaling through Notch activation following acute resistance exercise. PLoS One 8:e68743 (2013). PubMed: 23844238
  • Jin S  et al. Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKa/IKKß. Oncogene 32:4892-902 (2013). IHC-P ; Human . PubMed: 23178494
  • Regan JL  et al. Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner. Cell Rep 4:110-23 (2013). PubMed: 23810554
  • Yabuuchi S  et al. Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer. Cancer Lett 335:41-51 (2013). PubMed: 23402814
  • Bosse K  et al. Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. J Mol Cell Cardiol 60:27-35 (2013). ICC . PubMed: 23583836
  • Izumi N  et al. Fbxw7 controls angiogenesis by regulating endothelial Notch activity. PLoS One 7:e41116 (2012). WB . PubMed: 22848434
  • Tanveer R  et al. The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-ß and in the Cortex of Aged Rats. J Biol Chem 287:34709-21 (2012). PubMed: 22891244
  • Moya IM  et al. Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev Cell 22:501-14 (2012). PubMed: 22364862
  • Mizuma M  et al. The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models. Mol Cancer Ther 11:1999-2009 (2012). PubMed: 22752426
  • Rahman M  et al. Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis. Brain Res 1448:117-28 (2012). PubMed: 22353755
  • Shimada IS  et al. Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J Neurosci 32:7926-40 (2012). WB, IHC-Fr ; Mouse . PubMed: 22674268
  • Zou S  et al. Notch signaling in descending thoracic aortic aneurysm and dissection. PLoS One 7:e52833 (2012). IHC-P ; Human . PubMed: 23300792
  • Hardee ME  et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-ß. Cancer Res 72:4119-29 (2012). PubMed: 22693253
  • Chen L  et al. The Role of Notch 1 Activation in Cardiosphere Derived Cell Differentiation. Stem Cells Dev : (2012). PubMed: 22239539
  • Ng FS  et al. Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors. Clin Cancer Res 18:4122-35 (2012). IHC-P ; Mouse . PubMed: 22675171
  • Zhou D  et al. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A 108:E1312-20 (2011). PubMed: 22042863
  • Stamataki D  et al. Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system. PLoS One 6:e24484 (2011). IF . PubMed: 21915337
  • Piggott K  et al. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Circulation 123:309-18 (2011). PubMed: 21220737
  • Xin Y  et al. IKK1 control of epidermal differentiation is modulated by notch signaling. Am J Pathol 178:1568-77 (2011). PubMed: 21435444
  • Laforest B  et al. Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest 121: (2011). PubMed: 21633169
  • Murea M  et al. Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function. Kidney Int 78:514-22 (2010). PubMed: 20531454
  • Bielesz B  et al. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 120:4040-54 (2010). PubMed: 20978353
  • Hao L  et al. Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene 29:201-13 (2010). WB ; Human . PubMed: 19838210
  • Sethi S  et al. Molecular signature of epithelial-mesenchymal transition (EMT) in human prostate cancer bone metastasis. Am J Transl Res 3:90-9 (2010). IHC . PubMed: 21139809
  • Carlson ME  et al. Molecular aging and rejuvenation of human muscle stem cells. EMBO Mol Med 1:381-91 (2009). Human . PubMed: 20049743
  • Radke AL  et al. Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood 113:3092-101 (2009). Electron Microscopy, Flow Cyt ; Human . PubMed: 19171875
  • Rodilla V  et al. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A 106:6315-20 (2009). ChIP ; Human . PubMed: 19325125
  • Sivasankaran B  et al. Tenascin-C is a novel RBPJkappa-induced target gene for Notch signaling in gliomas. Cancer Res 69:458-65 (2009). IHC-P ; Human . PubMed: 19147558
  • Liu Z  et al. Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling. Cancer Biol Ther 8:1840-51 (2009). WB, IHC-P ; Human . PubMed: 19717984
  • Rasul S  et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer 100:1879-88 (2009). WB ; Human . PubMed: 19513078
  • Monticone M  et al. z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response. Mol Cancer Res 7:1822-34 (2009). PubMed: 19861404
  • Li Y  et al. Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation 119:2686-92 (2009). PubMed: 19433762
  • Carlson ME  et al. Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell 8:676-89 (2009). PubMed: 19732043
  • Song LL  et al. Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells. Oncogene 27:5833-44 (2008). WB ; Human . PubMed: 18560356
  • Ma QH  et al. A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis. Nat Cell Biol 10:283-94 (2008). WB ; Mouse . PubMed: 18278038
  • Brack AS  et al. A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis. Cell Stem Cell 2:50-9 (2008). ICC/IF, IHC-Fr ; Mouse . PubMed: 18371421
  • Grigorian A  et al. Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir. BMC Neurosci 9:27 (2008). ICC/IF ; Human . PubMed: 18302767
  • Keilani S & Sugaya K Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1. BMC Dev Biol 8:69 (2008). WB ; Human . PubMed: 18593473
  • Carlson ME  et al. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature 454:528-32 (2008). WB ; Mouse . PubMed: 18552838
  • Djalilian AR  et al. Down-regulation of Notch signaling during corneal epithelial proliferation. Mol Vis 14:1041-9 (2008). PubMed: 18552977
  • Efstratiadis A  et al. Notch, Myc and breast cancer. Cell Cycle 6:418-29 (2007). PubMed: 17329972
  • Niimi H  et al. Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol 176:695-707 (2007). PubMed: 17325209
  • Garg P  et al. Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation. Gastroenterology 132:1877-89 (2007). PubMed: 17484881
  • Vauclair S  et al. Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism. Dev Cell 13:242-53 (2007). IP . PubMed: 17681135
  • Estrach S  et al. Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development 133:4427-38 (2006). PubMed: 17035290
  • Liu ZJ  et al. Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1. FASEB J 20:1009-11 (2006). WB ; Human . PubMed: 16571776
  • Nemir M  et al. Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res 98:1471-8 (2006). PubMed: 16690879
  • Conboy IM  et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433:760-4 (2005). PubMed: 15716955
  • Balint K  et al. Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest 115:3166-76 (2005). WB ; Human . PubMed: 16239965
  • Milano J  et al. Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol Sci 82:341-58 (2004). PubMed: 15319485
  • Koenig SN  et al. Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background. J Cardiovasc Dev Dis 2:17-30 (0). IHC . PubMed: 25914885

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