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Product Name 

activated Notch1 peptide

Product type 

Proteins and Peptides

Peptide 

Synthetic peptide: VLLSRKRRRQHGQC, corresponding to amino acids 1755-1767 of Human activated Notch1.
BLAST 'VLLSRKRRRQHGQC' with BLAST the sequence with ExPASy or BLAST the sequence with NCBI

Tested applications 
(see key)

BL

Research areas 

Developmental Biology >> Embryogenesis >> Somatogenesis
Stem Cells >> Neural Stem Cells >> Neural Crest Stem Cells
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Stem Cells >> Neural Stem Cells >> Surface Molecules
Stem Cells >> Neural Stem Cells >> Intracellular
Stem Cells >> Signaling Pathways >> Notch >> Nuclear
Stem Cells >> Signaling Pathways >> Notch >> Surface Molecules
Chromatin and Nuclear Signaling >> Transcription >> Other factors
Neuroscience >> Neurology process >> Notch Pathway

Relevance 

Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. The protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands. Once the Notch extracellular domain interacts with a ligand, a protease called TACE (Tumor Necrosis Factor Alpha Converting Enzyme) cleaves the Notch protein just outside the membrane. This releases the extracellular portion of Notch, which continues to interact with the ligand. The ligand plus the Notch extracellular domain is then endocytosed by the ligand expressing cell. After this first cleavage, an enzyme called gamma-secretase cleaves the remaining part of the Notch protein just inside the inner leaflet of the cell membrane. This releases the intracellular portion of the Notch protein, which then moves to the nucleus and causes various genes to be expressed. There are many other proteins involved in the intracellular portion of the Notch signalling cascade.

This peptide can be used as a blocking peptide for the rabbit polyclonal to Notch-1 (ab8925).

 

Alternative names activated Notch1 peptide (ab730)

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this activated Notch1 peptide is on this datasheet. But please do contact us if you would like any reassurance!


 

Search PubMed (MEDLINE) for references to activated Notch1

 

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