Active Hepatitis A virus VP3 protein fragment (ab68371)

Overview

  • Product nameActive Hepatitis A virus VP3 protein fragment
  • DescriptionActive Hepatitis A virus VP3 protein fragment

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • Amino acids304 to 415

Specifications

Our Abpromise guarantee covers the use of ab68371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThis protein is immunoreactive with sera from HAV-infected individuals.
  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Purity> 90 % by SDS-PAGE.
    This protein was purified by proprietary chromatographic techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 0.1% SDS, 10mM CBB, pH 9.6.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • HAV VP3
    • Hepatitis A VP3 protein
    • Virion protein 3
    • VP3
  • RelevanceHepatitis A Virus (HAV) is a 27nm nonenveloped, spherical, positive stranded RNA virus, classified within the genus hepatovirus of the picornavirus family and is among the smallest and structurally simplest of the RNA animal viruses. A single large polyprotein is expressed from a large open reading frame extending through most of the genomic RNA. This polyprotein is subsequently cleaved by a viral protease (3Cpro) to form three (possibly four) capsid proteins and several nonstructural proteins. HAV genomic replication occurs exclusively in the cytoplasm of the infected hepatocyte by a mechanism involving an RNA-dependent RNA polymerase. Though he clinical picture of viral (A) hepatitis is extremely variable - ranging from asymptotic infection without jaundice to a fulminating disease and death in a few days, Hepatitis A is usually a mild illness and does not lead to chronic or persistent hepatitis. HAV is transmitted by the orofecal route and is still endemic throughout much of the world, including the western world. HAV exists worldwide as a single serotype with a small degree of antigenetic variation. Present evidence suggests that immunity acquired naturally (or from an inactivated hepatitis A vaccine) will protect against all human HAV strains.
  • Cellular localizationCytoplasmic

References for Active Hepatitis A virus VP3 protein fragment (ab68371)

ab68371 has not yet been referenced specifically in any publications.

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