Active hepatitis c virus Hepatitis C Virus Core 1b protein fragment (ab67745)

Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • SpeciesHepatitis C Virus
    • SequenceMSTNPKPQRK TKRNTNRRPQ DVKFPGVGQI VGGVYLLPRR GPRLGVRATR KTSERSQPRG RRQPIPKARR PEGRTWAQPG YPWPLYGNEG CGWAGWLLSP RGSRPSWGPT DPRRRSRNLG KVIDTLTCGF ADLMGYIPLV GAPLGGAARA LAHGVRVLED GVNYATGNLP GCSFSIFLLA LLSCLTVPA
    • Molecular weight22 kDa
    • Amino acids2 to 192
    • Additional sequence informationFused with b-galactosidase (114 kDa) at N-terminus.

Specifications

Our Abpromise guarantee covers the use of ab67745 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThis protein is immunoreactive with sera of HCV-infected individuals.
  • Applications

    Western blot

    ELISA

  • Purity> 95 % by SDS-PAGE.
    This protein was purified by proprietary chromatographic techniques.
  • FormLiquid
  • Additional Notes

    test .

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • Capsid protein C
    • Core protein p19
    • Core protein p21
    • Hepatitis C virus core protein
  • RelevanceHCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. There are over 20 different subtypes of Hepatitis C Virus; HCV type 1b is mostly found in Europe and Asia. The prevalence of HCV type 1b infection has recently decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b are independent predictors for poor response to interferon-alpha therapy. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.
  • Cellular localizationSecreted; Host endoplasmic reticulum membrane; Single-pass membrane protein; Host nucleus; Host cytoplasm.

References for Active hepatitis c virus Hepatitis C Virus Core 1b protein fragment (ab67745)

ab67745 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. Unfortunately, we have not tested the LPS (lipopolysaccharide) levels for this product to date, so it might contain a bit since we do use pyrogen free water for the purification. Regarding suitable products, I am afr...

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