Active hepatitis c virus Hepatitis C Virus Core 1b protein fragment (ab67745)
- Product nameActive hepatitis c virus Hepatitis C Virus Core 1b protein fragmentSee all Hepatitis C Virus Core 1b proteins and peptides ...
- SourceE. coli
- Amino Acid Sequence
- SpeciesHepatitis C Virus
- SequenceMSTNPKPQRK TKRNTNRRPQ DVKFPGVGQI VGGVYLLPRR GPRLGVRATR KTSERSQPRG RRQPIPKARR PEGRTWAQPG YPWPLYGNEG CGWAGWLLSP RGSRPSWGPT DPRRRSRNLG KVIDTLTCGF ADLMGYIPLV GAPLGGAARA LAHGVRVLED GVNYATGNLP GCSFSIFLLA LLSCLTVPA
- Molecular weight22 kDa
- Amino acids2 to 192
- Additional sequence informationFused with b-galactosidase (114 kDa) at N-terminus.
Our Abpromise guarantee covers the use of ab67745 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Biological activityThis protein is immunoreactive with sera of HCV-infected individuals.
- Purity> 95
% by SDS-PAGE.
This protein was purified by proprietary chromatographic techniques.
- Additional Notes
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8.0
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Capsid protein C
- Core protein p19
- Core protein p21
- Hepatitis C virus core protein
- RelevanceHCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. There are over 20 different subtypes of Hepatitis C Virus; HCV type 1b is mostly found in Europe and Asia. The prevalence of HCV type 1b infection has recently decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b are independent predictors for poor response to interferon-alpha therapy. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.
References for Active hepatitis c virus Hepatitis C Virus Core 1b protein fragment (ab67745)
ab67745 has not yet been referenced specifically in any publications.