Active hepatitis c virus Hepatitis C Virus genotype 1a NS5 protein fragment (ab68373)

Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • SpeciesHepatitis C Virus
    • Amino acids2212 to 2313

Specifications

Our Abpromise guarantee covers the use of ab68373 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThis protein is immunoreactive with sera of HCV-infected individuals.
  • Applications

    Western blot

    ELISA

  • Purity> 95 % by SDS-PAGE.
    This protein was purified by proprietary chromatographic techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 0.2% Triton-X, 1.5M Urea, 25mM Tris HCl, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • HCV 1a NS5
    • Hepatitis C virus NS5A
    • Non-structural protein 5A
    • p56
  • RelevanceHepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B (non-structural protein 5B) is an RNA-dependant RNA polymerase responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication. Hepatitis C virus (HCV) can cause chronic hepatitis, cirrhosis and hepatocellular carcinoma. At present there is no vaccine effective against HCV.
  • Cellular localizationEndoplasmic reticulum membrane

References for Active hepatitis c virus Hepatitis C Virus genotype 1a NS5 protein fragment (ab68373)

ab68373 has not yet been referenced specifically in any publications.

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