Active hepatitis c virus Hepatitis C Virus Genotype 1c NS3 protein fragment (ab67963)

Overview

  • Product nameActive hepatitis c virus Hepatitis C Virus Genotype 1c NS3 protein fragment

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • SpeciesHepatitis C Virus
    • Amino acids1192 to 1459

Specifications

Our Abpromise guarantee covers the use of ab67963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThis protein is immunoreactive with sera of HCV-infected individuals.
  • Applications

    Western blot

    ELISA

  • Purity> 95 % by SDS-PAGE.
    ab67963 was purified by proprietary chromatographic techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 0.2% Triton-X, 1.5M Urea, 25mM Tris HCl, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • HCV NS3 Ic
    • Hepatitis C virus NS3 protein
    • NS3 protein
    • p23
  • RelevanceHCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins including NS3, and several non-structural proteins necessary for viral replication. The NS3 part of the polyprotein displays three enzymatic activities: serine protease, NTPase and RNA helicase. The NS3 serine proteinase (NS3P) is a non-structural hepatitis C protein responsible for proteolytic processing of other non-structural proteins; because of this, it is also the most extensively studied protein of the Hepatitis C genome. It is responsible for proteolytic processing of the entire downstream region of the HC polyprotein, catalyzing cleavage at the NS3/NS4a, NS4a/NS4b, NS4b/NS5a, and NS5a/NS5b sites to release the mature NS3, NS4a, NS4b, NS5a, and NS5b proteins.For proper function, NS3 requires NS4a as a cofactor, but, interestingly enough, NS3 also cleaves the NS4a protein.
  • Cellular localizationEndoplasmic reticulum

References for Active hepatitis c virus Hepatitis C Virus Genotype 1c NS3 protein fragment (ab67963)

ab67963 has not yet been referenced specifically in any publications.

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