Active human Activin Receptor Type IA protein fragment (ab84539)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceLLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN SLDKLKTD
    • Amino acids147 to 509

Specifications

Our Abpromise guarantee covers the use of ab84539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe specific activity of Activin Receptor Type IA was determined to be 46 nmol/min/mg by activity assay.
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Purity> 90 % by SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • Activin A receptor type I
    • Activin A receptor type II like kinase 2
    • Activin receptor type I
    • Activin receptor type-1
    • Activin receptor-like kinase 2
    • ACTR-I
    • ACTRI
    • ACVR1
    • ACVR1_HUMAN
    • ACVR1A
    • ACVRLK2
    • ALK 2
    • ALK-2
    • ALK2
    • FOP
    • Hydroxyalkyl protein kinase
    • Serine/threonine-protein kinase receptor R1
    • SKR1
    • TGF-B superfamily receptor type I
    • TGFB superfamily receptor type I
    • TSR-I
    • TSRI
    see all
  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
  • Tissue specificityExpressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
  • Involvement in diseaseDefects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Target information above from: UniProt accession Q04771 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Active human Activin Receptor Type IA protein fragment images

  • The specific activity of ab84539 was determined to be 46 nmol/min/mg by activity assay.
  • The purity of ab84539 was determined to be >90% by SDS-PAGE. Molecular Weight: 67 kDa.

References for Active human Activin Receptor Type IA protein fragment (ab84539)

ab84539 has not yet been referenced specifically in any publications.

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