Active human Alpha 2 Antiplasmin full length protein (ab77936)

Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab77936 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific activity: 13.05 IU/mg ab77936 efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots.
  • Applications

    SDS-PAGE

    Western blot

  • Purity> 95 % by SDS-PAGE.

  • FormLyophilised
  • Additional NotesAll human source materials have tested negative for HIV1, HIV2, HBc, HCV antibodies and HBsAg by FDA approved tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.


    Found in plasma in about 70ug/ml.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Store at -20°C. Stable for 12 months at -20°C

    Preservative: None
    Constituents: 200mM Sodium chloride, 20mM Bis-Tris, pH 6.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionReconstitution is batch dependent. We deliver 100ug lyophilised product. Please add the correct volume of distilled water to achieve the lot specific concentration indicated on the vial.

General info

  • Alternative names
    • A2AP
    • A2AP_HUMAN
    • AAP
    • Alpha 2 antiplasmin
    • Alpha 2 antiplasmin pigment epithelium derived factor
    • Alpha 2 AP
    • ALPHA 2 PI
    • Alpha 2 plasmin inhibitor
    • Alpha 2 plasmin inhibitor deficiency
    • Alpha-2-antiplasmin
    • Alpha-2-AP
    • Alpha-2-PI
    • Alpha-2-plasmin inhibitor
    • Antiplasmin deficiency
    • API
    • Plasmin inhibitor deficiency
    • PLI
    • Serine (or cysteine) peptidase inhibitor, clade F, member 2
    • Serine (Or cysteine) peptidase inhibitor, clade F, member 2, isoform CRA_c
    • Serine (or cysteine) proteinase inhibitor, clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2
    • Serine (Or cysteine) proteinase inhibitor, clade F, member 2
    • Serine or cysteine peptidase inhibitor clade F member 2
    • Serpin F2
    • Serpin peptidase inhibitor clade F
    • Serpin peptidase inhibitor, clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2
    • SERPINF2
    see all
  • FunctionSerine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
  • Tissue specificityExpressed by the liver and secreted in plasma.
  • Involvement in diseaseDefects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]. APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis.
  • Sequence similaritiesBelongs to the serpin family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Active human Alpha 2 Antiplasmin full length protein (ab77936)

This product has been referenced in:
  • Eddy JL  et al. Production of outer membrane vesicles by the plague pathogen Yersinia pestis. PLoS One 9:e107002 (2014). Read more (PubMed: 25198697) »
  • Wang L  et al. Degradation of Internalized avß5 Integrin Is Controlled by uPAR Bound uPA: Effect on ß1 Integrin Activity and a-SMA Stress Fiber Assembly. PLoS One 7:e33915 (2012). Read more (PubMed: 22470492) »

See all 3 Publications for this product

Product Wall

Vielen Dank für Ihren Anruf. Bitte entschuldigen Sie meine anfängliche Verwirrung. Ihr Röhrchen enthält 100ug Protein, dass vor der Gefriertrocknung eine Konzentration von 3.24mg/ml aufwies. Da auch der Puffer gefriergetrocknet wur...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"