Active human BMP3 full length protein (ab97412)

Overview

Description

  • NatureRecombinant
  • SourceHEK 293 cells
  • Amino Acid Sequence
    • AccessionP12645
    • SpeciesHuman
    • SequenceMQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPMPKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD ENKNVVLKVY PNMTVESCAC R
    • Molecular weight13 kDa
    • Amino acids363 to 472

Specifications

Our Abpromise guarantee covers the use of ab97412 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityDetermined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Endotoxin level< 1.000 Eu/µg
  • Purity> 95 % by SDS-PAGE.
    Purity is greater than 95% by SDS-PAGE gel and HPLC analyses.
  • FormLyophilised
  • Additional NotesDetermined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells. Determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionThe lyophilized protein is stable at room temperature for up to 1 month. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C.

General info

  • Alternative names
    • BMP-3
    • BMP-3A
    • bmp3
    • BMP3_HUMAN
    • BMP3A
    • Bone morphogenetic protein 3
    • Bone morphogenetic protein 3 (osteogenic)
    • Bone morphogenetic protein 3A
    • Osteogenin
    see all
  • FunctionNegatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
  • Tissue specificityExpressed in adult and fetal cartilage.
  • Sequence similaritiesBelongs to the TGF-beta family.
  • Cellular localizationSecreted.
  • Target information above from: UniProt accession P12645 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Active human BMP3 full length protein (ab97412)

ab97412 has not yet been referenced specifically in any publications.

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