Active human BMP9 protein fragment (ab94350)

Overview

Description

  • NatureRecombinant
  • SourceCHO
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceSAGAGSHCQK TSLRVNFEDI GWDSWIIAPK EYEAYECKGG CFFPLADDVT PTKHAIVQTL VHLKFPTKVG KACCVPTKLS PISVLYKDDM GVPTLKYHYE GMSVAECGCR
    • Amino acids320 to 429

Specifications

Our Abpromise guarantee covers the use of ab94350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml.
  • Applications

    SDS-PAGE

  • Purity> 95 % by SDS-PAGE.
    Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • BMP 9
    • Bone morphogenetic protein 9
    • GDF 2
    • GDF2
    • growth differentiation factor 2
    • Growth/differentiation factor 2
    see all
  • RelevanceBMP9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. They are regulators of cell growth and differentiation. BMP9 has a role in the maturation of BFCN (basal forebrain cholinergic neurons) also inducing and maintaining the ability of these cells to respond to acetylcholine; BFCN are important for the processes of learning, memory and attention. BMP9 is a potent inducer of hepcidin (a cationic peptide that has a antimicrobial properties) in hepatocytes and can regulate iron metabolism. The physiological receptor of BMP9 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family. BMP9 is one of the most potent BMPs to induce orthotopic bone formation in vivo. BMP3, a blocker of most BMPs seems not to affect BMP9.
  • Cellular localizationSecreted

References for Active human BMP9 protein fragment (ab94350)

ab94350 has not yet been referenced specifically in any publications.

Product Wall

Thank you very much for your inquiry.

I can confirm that ab94350 is only a fragment of the BMP9 protein.

We have preliminary results that it is biological active. This was determined by its ability to induce alkaline phosphatase p...

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