Active human c Abl peptide (ab69810)
- Product nameActive human c Abl peptideSee all c Abl proteins and peptides ...
- DescriptionRecombinant, His tag
- SourceBaculovirus infected sf9 cells
- Amino Acid Sequence
- Amino acids27 to 1130
- TagsHis tag N-Terminus
Our Abpromise guarantee covers the use of ab69810 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Biological activity
Specific activity: 871 nmol/min/mg
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Abelson Murine Leukemia Viral Oncogene Homolog 1
- Abelson murine leukemia viral v abl oncogene homolog 1
- Abelson tyrosine protein kinase 1
- Abl 1
- Abl protein
- Bcr/c abl oncogene protein
- c abl oncogene 1 non receptor tyrosine kinase
- c abl oncogene 1 receptor tyrosine kinase
- JTK 7
- Proto oncogene tyrosine protein kinase ABL1
- Proto-oncogene c-Abl
- Transformation gene oncogene ABL
- Tyrosine-protein kinase ABL1
- v abl
- v abl Abelson murine leukemia viral oncogene homolog 1
- FunctionProtein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
- Tissue specificityWidely expressed.
- Involvement in diseaseNote=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
- Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.
modificationsPhosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation (By similarity). Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for cytoplasmic translocation.
Isoform IB is myristoylated on Gly-2.
- Cellular localizationCytoplasm > cytoskeleton. Nucleus. Sequestered into the cytoplasm through interaction with 14-3-3 proteins and Nucleus membrane. The myristoylated c-ABL protein is reported to be nuclear.
Active human c Abl peptide images
Kinase activity assay of ab69810. The specific activity of c-Abl was determined to be 871 nmol/min/mg.
SDS-PAGE of ab69810. Molecular weight 135kDa.
References for Active human c Abl peptide (ab69810)
ab69810 has not yet been referenced specifically in any publications.