Active human DCAMKL2 protein fragment (ab85758)

Overview

  • Product nameActive human DCAMKL2 protein fragment
  • DescriptionActive human DCAMKL2 protein fragment

Description

  • NatureRecombinant
  • SourceBaculovirus infected sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids1 to 690

Specifications

Our Abpromise guarantee covers the use of ab85758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe Specific activity of ab85758 was determined to be 94 nmol/min/mg.
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • CaMK-like CREB regulatory kinase 2
    • CL2
    • CLICK-II
    • CLICK2
    • DCAMK L2
    • DCAMKL 2
    • DCDC 3
    • DCDC 3B
    • DCDC3
    • DCDC3B
    • DCK 2
    • DCK2
    • DCLK 2
    • DCLK2
    • DCLK2_HUMAN
    • DKFZp761I032
    • Doublecortin and CaM kinase like 2
    • Doublecortin domain-containing protein 3B
    • Doublecortin like and CAM kinase like 2
    • Doublecortin like kinase 2
    • Doublecortin-like and CAM kinase-like 2
    • Doublecortin-like kinase 2
    • MGC45428
    • Serine/threonine protein kinase DCLK2
    • Serine/threonine-protein kinase DCLK2
    see all
  • FunctionProtein kinase with a significantly reduced Ca2+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 2 doublecortin domains.
    Contains 1 protein kinase domain.
  • DomainThe doublecortin domains are involved in the colocalization with microtubules.
  • Cellular localizationCytoplasm > cytoskeleton. Colocalizes with microtubules.
  • Information by UniProt

Active human DCAMKL2 protein fragment images

  • The Specific activity of ab85758 was determined to be 94 nmol/min/mg.
  • SDS-PAGE showing ab85758 at approximately 105kDa.

References for Active human DCAMKL2 protein fragment (ab85758)

ab85758 has not yet been referenced specifically in any publications.

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