This product is an active protein and may elicit a biological response in vivo, handle with caution.
eIF4E binding protein 1
eIF4E-binding protein 1
Eukaryotic translation initiation factor 4E-binding protein 1
Phosphorylated heat- and acid-stable protein regulated by insulin 1
Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Belongs to the eIF4E-binding protein family.
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR.
Col E et al. Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock. Sci Rep7:5418 (2017).
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