Active human Eph receptor A4 protein fragment (ab84575)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids610 to 887

Specifications

Our Abpromise guarantee covers the use of ab84575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific activity of Eph receptor A4 was determined to be 83 nmol/min/mg as per activity assay protocol.
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Purity> 90 % by SDS-PAGE.
    Purity was determined to be >90% by densitometry.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • Cek 8
    • CEK8
    • EK8
    • eph receptor a4
    • EPH-like kinase 8
    • EphA4
    • EPHA4_HUMAN
    • Ephrin type-A receptor 4
    • HEK 8
    • hEK8
    • Receptor protein-tyrosine kinase HEK8
    • SEK
    • Sek 1
    • TYRO 1 protein tyrosine kinase
    • TYRO1
    • Tyrosine-protein kinase receptor SEK
    • Tyrosine-protein kinase TYRO1
    see all
  • FunctionReceptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • DomainThe protein kinase domain mediates interaction with NGEF/ephexin-1.
  • Cellular localizationMembrane.
  • Target information above from: UniProt accession P54764 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Active human Eph receptor A4 protein fragment images

  • Specific activity of Eph receptor A4 was determined to be 83 nmol/min/mg as per activity assay protocol.
  • Purity of Eph receptor A4 was determined to be >90% by densitometry. approx, MW 58kDa.

References for Active human Eph receptor A4 protein fragment (ab84575)

ab84575 has not yet been referenced specifically in any publications.

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