Active human GDNF full length protein (ab73450)
- Product nameActive human GDNF full length proteinSee all GDNF proteins and peptides ...
- SourceE. coli
- Amino Acid Sequence
- SequenceThe sequence of the first five N-terminal amino acids was determined and was found to be Met-Ser-Pro-Asp-Lys.
- Amino acids0 to 0
Our Abpromise guarantee covers the use of ab73450 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Purity> 95
% by SDS-PAGE.
ab73450 is purified by proprietary chromatographic techniques. Purity is greater than 98.0% as determined by RP-HPLC and SDS-PAGE.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 150mM Sodium chloride, 10mM Sodium citrate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- ReconstitutionReconstitute in sterile 18MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
- Astrocyte derived trophic factor
- Astrocyte derived trophic factor 1
- Astrocyte-derived trophic factor
- ATF 1
- ATF 2
- Glial cell derived neurotrophic factor
- Glial Cell Line Derived Neurotrophic Factor
- Glial cell line-derived neurotrophic factor
- Glial derived neurotrophic factor
- HFB1 GDNF
- FunctionNeurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
- Tissue specificityIn the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
- Involvement in diseaseDefects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
- Sequence similaritiesBelongs to the TGF-beta family. GDNF subfamily.
- Cellular localizationSecreted.
Active human GDNF full length protein images
Anti-GDNF antibody (ab28956) at 1/500 dilution +
Active human GDNF full length protein (ab73450) at 0.1 µg
Goat polyclonal Secondary Antibody to Chicken IgY - H&L (HRP) at 1/3000 dilution
developed using the ECL technique
Performed under reducing conditions.
Exposure time : 3 minutes
References for Active human GDNF full length protein (ab73450)
ab73450 has not yet been referenced specifically in any publications.