Active human Integrin beta 4 (phospho Y1494) peptide (ab42718)

Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • Modificationsphospho Y1494

Associated products

Specifications

Our Abpromise guarantee covers the use of ab42718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe peptide is specifically recognized by anti-Integrin-ß4 (Tyr-1494) phospho-specific antibody (ab29043) in ELISA, and has been shown to block the reactivity of ab29043 during Western blot. In addition, the peptide is recommended for use in blocking ab29043 reactivity in immunocytochemistry.
  • Applications

    Blocking - Blocking peptide for Anti-Integrin beta 4 (phospho Y1494) antibody (ab29043)

    ELISA

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • CD 104
    • CD104
    • CD104 antigen
    • gp150
    • Integrin beta 4 subunit
    • Integrin beta-4
    • ITB4_HUMAN
    • ITG B4
    • ITGB 4
    • Itgb4
    see all
  • FunctionIntegrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
  • Tissue specificityIntegrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
  • Involvement in diseaseDefects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
    Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
  • Sequence similaritiesBelongs to the integrin beta chain family.
    Contains 1 Calx-beta domain.
    Contains 4 fibronectin type-III domains.
    Contains 1 PSI domain.
    Contains 1 VWFA domain.
  • DomainThe fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Active human Integrin beta 4 (phospho Y1494) peptide (ab42718)

ab42718 has not yet been referenced specifically in any publications.

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