Active human NMNAT2 full length protein (ab109152)
- Product nameActive human NMNAT2 full length proteinSee all NMNAT2 proteins and peptides ...
- DescriptionRecombinant, His tag
- SourceE. coli
- Amino Acid Sequence
- Molecular weight35 kDa including tags
- Amino acids2 to 307
- TagsHis tag N-Terminus
Our Abpromise guarantee covers the use of ab109152 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Biological activityConverts NMN to NAD+.
- Purity> 90
% by SDS-PAGE.
ab109152 is 0.2µm filtered
- Additional NotesWorking aliquots are stable for up to 3 months when stored at -20°C. Converts NMN to NAD+.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- NaMN adenylyltransferase 2
- Nicotinamide mononucleotide adenylyltransferase 2
- Nicotinamide nucleotide adenylyltransferase 2
- Nicotinate-nucleotide adenylyltransferase 2
- NMN adenylyltransferase 2
- NMNAT 2
- PNAT 2
- Pyridine nucleotide adenylyltransferase 2
- FunctionCatalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannnot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+).
- Tissue specificityHighly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.
- PathwayCofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
- Sequence similaritiesBelongs to the eukaryotic NMN adenylyltransferase family.
- Cellular localizationCytoplasm. Golgi apparatus.
References for Active human NMNAT2 full length protein (ab109152)
ab109152 has not yet been referenced specifically in any publications.