Active human NMNAT2 full length protein (ab109152)

Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • AccessionQ9BZQ4
    • SpeciesHuman
    • Molecular weight35 kDa including tags
    • Amino acids2 to 307
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab109152 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityConverts NMN to NAD+.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity> 90 % by SDS-PAGE.
    ab109152 is 0.2µm filtered
  • FormLiquid
  • Additional NotesWorking aliquots are stable for up to 3 months when stored at -20°C. Converts NMN to NAD+.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General info

  • Alternative names
    • C1orf15
    • KIAA0479
    • MGC2756
    • NaMN adenylyltransferase 2
    • Nicotinamide mononucleotide adenylyltransferase 2
    • Nicotinamide nucleotide adenylyltransferase 2
    • Nicotinate-nucleotide adenylyltransferase 2
    • NMN adenylyltransferase 2
    • NMNA2_HUMAN
    • NMNAT 2
    • Nmnat2
    • PNAT 2
    • PNAT2
    • Pyridine nucleotide adenylyltransferase 2
    see all
  • FunctionCatalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannnot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+).
  • Tissue specificityHighly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.
  • PathwayCofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
  • Sequence similaritiesBelongs to the eukaryotic NMN adenylyltransferase family.
  • Cellular localizationCytoplasm. Golgi apparatus.
  • Target information above from: UniProt accession Q9BZQ4 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Active human NMNAT2 full length protein (ab109152)

ab109152 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab109152.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"