Active human Parathyroid Hormone peptide (ab68899)

Overview

Description

  • NatureSynthetic
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceLMH NLGKHLNSME RVEWLRKKLQ DVHNF
    • Molecular weight3 kDa
    • Amino acids7 to 34

Specifications

Our Abpromise guarantee covers the use of ab68899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe activity calculated by UMR106 cell/cAMP method corresponds to a specific activity of 1.0 x 104 Units/mg.
  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    Purity is greater than 97.0% as determined by analysis by RP-HPLC and SDS-PAGE, purified by proprietary chromatographic techniques.
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 4% Mannitol, 20mM PBS, pH 7

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionReconstitute in sterile 18MOhm/cm water to not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

General Info

  • Alternative names
    • hPTH
    • Parathormone
    • Parathyrin
    • Parathyroid hormone
    • Parathyroid hormone 1
    • PTH
    • PTH1
    • PTH1 receptor
    • PTH1R
    • PTHR
    • PTHR1
    • PTHY_HUMAN
    see all
  • FunctionPTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
  • Involvement in diseaseDefects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
  • Sequence similaritiesBelongs to the parathyroid hormone family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Active human Parathyroid Hormone peptide (ab68899)

ab68899 has not yet been referenced specifically in any publications.

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