Active human PIK3CG + PIK3R5 full length protein (ab68181)
- Product nameActive human PIK3CG + PIK3R5 full length protein
- SourceBaculovirus infected sf9 cells
- Amino Acid Sequence
- Amino acids0 to 0
Our Abpromise guarantee covers the use of ab68181 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Biological activityActivity: ~ 3 nmol/mg/min using phosphatidylinositol as the substrate.
- Purity> 95
% by SDS-PAGE.
- Additional NotesFor long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol, 25mM Sodium chloride, 25mM HEPES, 2.5mM Magnesium chloride, pH 8.0
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- P101 PI3K
- p120 PI3K
- PI3 kinase catalitic gamma polypetide
- PI3 kinase regulatory subunit 5
- Protein FOAP 2
- RelevancePI3 Kinase catalytic subunit gamma belongs to a family of lipid kinases that are implicated in signal transduction. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. It forms a heterodimer of a catalytic subunit (PI3 Kinase catalytic subunit gamma/p120) with the regulatory (PIK3R5/p101) subunit. PI3KR5 is a receptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatory subunit.
- Cellular localizationPIK3R5: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein.
References for Active human PIK3CG + PIK3R5 full length protein (ab68181)
ab68181 has not yet been referenced specifically in any publications.