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- Amino Acid Sequence
Our Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Biological activityThis peptide is used for blocking the activity of the Anti-RHEB antibody (ab25873).
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Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Ras homolog enriched in brain 2, formerly
- GTP binding protein Rheb
- GTP-binding protein Rheb
- FunctionStimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.
- Tissue specificityUbiquitous. Highest levels observed in skeletal and cardiac muscle.
- Sequence similaritiesBelongs to the small GTPase superfamily. Rheb family.
modificationsFarnesylation is important for efficiently activating mTORC1-mediated signaling.
- Cellular localizationCell membrane.
Information by UniProt
References for Active human RHEB peptide (ab39861)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"