This product is an active protein and may elicit a biological response in vivo, handle with caution.
Lymphocyte antigen 64
lymphocyte antigen 64 radioprotective 105kDa
lymphocyte antigen-64, radioprotective, 105kDa
Radioprotective 105 kDa protein
FunctionMay cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
Tissue specificityExpressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Sequence similaritiesBelongs to the Toll-like receptor family. Contains 19 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.