SequenceSemaphorin 3A synthetic peptide corresponds to amino acids in the
central region of human Sema3A. This sequence is highly conserved in
rat and mouse Sema3A, and has low homology to other semaphorin
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe peptide is specifically recognized by anti-Sema3A
(Central region) antibody (ab23393) in ELISA, and has
been shown to block the reactivity of ab23393 during
Western blot. In addition, the peptide is recommended
for use in blocking ab23393 reactivity in
Blocking - Blocking peptide for Anti-Semaphorin 3A antibody (ab23393)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Semaphorin like growth cone guidance homolog of chick collapsin
RelevanceOne family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. Semaphorin 3A (Sema3A) may play a particularly interesting role in limiting axon regeneration since it is expressed in meningeal fibroblasts that invade the injured spinal cord and surround the glial scar. In addition, the Sema3A co receptors, Neuropilin 1 and Plexin A1, are expressed on axons that regenerate up to the injured region, but do not cross this Sema3A containing region. Thus, Sema3A and its co receptors may have important roles in regulating axon guidance during neuronal development and after neuronal injury.
References for Active human Semaphorin 3A peptide (ab88818)
has not yet been referenced specifically in any publications.
Publishing research using ab88818? Please let us know so that we can cite the reference in this datasheet.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"