Active human Semaphorin 3A peptide (ab88818)

Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceSemaphorin 3A synthetic peptide corresponds to amino acids in the central region of human Sema3A. This sequence is highly conserved in rat and mouse Sema3A, and has low homology to other semaphorin family members.

Associated products

Specifications

Our Abpromise guarantee covers the use of ab88818 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe peptide is specifically recognized by anti-Sema3A (Central region) antibody (ab23393) in ELISA, and has been shown to block the reactivity of ab23393 during Western blot. In addition, the peptide is recommended for use in blocking ab23393 reactivity in immunocytochemistry.
  • Applications

    Blocking - Blocking peptide for Anti-Semaphorin 3A antibody (ab23393)

    ELISA

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Coll 1
    • Coll1
    • HH16
    • Hsema I
    • Hsema III
    • Sema domain immunoglobulin domain (Ig) short basic domain secreted (semaphorin) 3A
    • Sema III
    • SEMA1
    • SEMA1-PEN
    • SEMA3A
    • SEMAD
    • SEMAIII
    • SEMAL
    • Semaphorin 3A precursor
    • Semaphorin III
    • Semaphorin like growth cone guidance homolog of chick collapsin
    • Semaphorin3A
    • SemD
    see all
  • RelevanceOne family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. Semaphorin 3A (Sema3A) may play a particularly interesting role in limiting axon regeneration since it is expressed in meningeal fibroblasts that invade the injured spinal cord and surround the glial scar. In addition, the Sema3A co receptors, Neuropilin 1 and Plexin A1, are expressed on axons that regenerate up to the injured region, but do not cross this Sema3A containing region. Thus, Sema3A and its co receptors may have important roles in regulating axon guidance during neuronal development and after neuronal injury.
  • Cellular localizationSecreted

References for Active human Semaphorin 3A peptide (ab88818)

ab88818 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab88818.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"