This product is an active protein and may elicit a biological response in vivo, handle with caution.
Toll interacting protein
FunctionComponent of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.
Sequence similaritiesBelongs to the tollip family. Contains 1 C2 domain. Contains 1 CUE domain.
Post-translational modificationsPhosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.