Active human UCH37 full length protein (ab124871)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ9Y5K5
    • SpeciesHuman
    • SequenceMGSSHHHHHHSSGLVPRGSH MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS FDAAMKGLAL SNSDVIRQVH NSFARQQMFE FDTKTSAKEE DAFHFVSYVP VNGRLYELDG LREGPIDLGA CNQDDWISAV RPVIEKRIQK YSEGEIRFNL MAIVSDRKMI YEQKIAELQR QLAEEEPMDT DQGNSMLSAI QSEVAKNQML IEEEVQKLKR YKIENIRRKH NYLPFIMELL KTLAEHQQLI PLVEKAKEKQ NAKKAQETK
    • Molecular weight40 kDa including tags
    • Amino acids1 to 329
    • TagsHis tag N-Terminus
    • Additional sequence informationUCHL5 produced in E.Coli is a single, non-glycosylated polypeptide chain containing349 amino acids (1-329a.a.) and having a molecular mass of 39.7kDa.

Specifications

Our Abpromise guarantee covers the use of ab124871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific activity: > 500 pmole/min/ug. Measured by the hydrolysis of Ubiquitin-AMC at pH 8.0, at 37°C.
  • Applications

    SDS-PAGE

    Functional Studies

  • Purity> 90 % SDS-PAGE.
    ab124871 is purified by proprietary chromatographic techniques and is sterile filtered.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.002% PMSF, 0.08% DTT, 0.32% Tris HCl, 0.06% EDTA, 30% Glycerol, 1.17% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • UCH37
    • AD-019
    • CGI 70
    • INO80 complex subunit R
    • INO80R
    • Ubiquitin C terminal hydrolase UCH37
    • Ubiquitin C-terminal hydrolase UCH37
    • Ubiquitin carboxyl terminal esterase L5
    • Ubiquitin carboxyl terminal hydrolase isozyme L5
    • Ubiquitin carboxyl terminal hydrolase L5
    • Ubiquitin carboxyl-terminal hydrolase isozyme L5
    • Ubiquitin thioesterase L5
    • Ubiquitin thiolesterase L5
    • UCH L5
    • UCH-L5
    • UCHL5
    • UCHL5_HUMAN
    see all
  • FunctionProtease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome.
  • Sequence similaritiesBelongs to the peptidase C12 family.
  • Cellular localizationCytoplasm. Nucleus. Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.
  • Information by UniProt

References for Active human UCH37 full length protein (ab124871)

ab124871 has not yet been referenced specifically in any publications.

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