Active mouse MAPK10 full length protein (ab119734)
- Product nameActive mouse MAPK10 full length proteinSee all MAPK10 proteins and peptides ...
- SourceBaculovirus infected sf9 cells
- Amino Acid Sequence
- Molecular weight71 kDa including tags
- Amino acids1 to 464
Our Abpromise guarantee covers the use of ab119734 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Biological activitySpecific Activity: 35 nmol/min/mg
- Purity> 80
% by SDS-PAGE.
Purity determined to be >80% by densitometry.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.79% Tris HCl, 25% Glycerol, 0.004% DTT, 0.003% EDTA, 0.31% Glutathione, 0.002% PMSF, 0.88% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- c Jun kinase 3
- c-Jun N-terminal kinase 3
- cJun N terminal kinase 3
- JNK3 alpha protein kinase
- MAP kinase
- MAP kinase 10
- MAP kinase p49 3F12
- MAPK 10
- mitogen activated protein kinase 10
- Mitogen-activated protein kinase 10
- protein kinase mitogen activated 10
- Stress activated protein kinase 1b
- stress activated protein kinase beta
- Stress activated protein kinase JNK3
- Stress-activated protein kinase JNK3
- FunctionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity.
- Tissue specificitySpecific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
- Involvement in diseaseDefects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:606369]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
- Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain.
- DomainThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
modificationsDually phosphorylated on Thr-221 and Tyr-223, which activates the enzyme. Weakly autophosphorylated on threonine and tyrosine residues in vitro.
- Cellular localizationCytoplasm.
Active mouse MAPK10 full length protein images
The specific activity of ab119734 was determined to be 35 nmol/min/mg.
SDS-PAGE analysis of ab119374.
References for Active mouse MAPK10 full length protein (ab119734)
ab119734 has not yet been referenced specifically in any publications.