Anti-Activin A Receptor Type IB/ALK-4 antibody [MM0054-11A7] (ab78415)
Key features and details
- Mouse monoclonal [MM0054-11A7] to Activin A Receptor Type IB/ALK-4
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG1
Overview
-
Product name
Anti-Activin A Receptor Type IB/ALK-4 antibody [MM0054-11A7]
See all Activin A Receptor Type IB/ALK-4 primary antibodies -
Description
Mouse monoclonal [MM0054-11A7] to Activin A Receptor Type IB/ALK-4 -
Host species
Mouse -
Specificity
ab78415 detects Activin A Receptor Type IB (ALK4). No cross reactivity was found to Activin A Receptor Type IA (ALK2). -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human Activin A Receptor Type IB/ALK-4 (extracellular).
-
Positive control
- WB: Human embryonic tissue lysate. IHC-P: Human placental tissue.
-
General notes
This antibody was produced from a hybridoma (mouse myeloma) fused with spleen cells from an immunized mouse.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
-
Purity
Protein G purified -
Primary antibody notes
This antibody was produced from a hybridoma (mouse myeloma) fused with spleen cells from an immunized mouse. -
Clonality
Monoclonal -
Clone number
MM0054-11A7 -
Isotype
IgG1 -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab78415 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/100 - 1/1000. Predicted molecular weight: 57 kDa.
|
|
IHC-P |
1/50.
|
Notes |
---|
WB
1/100 - 1/1000. Predicted molecular weight: 57 kDa. |
IHC-P
1/50. |
Target
-
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2. -
Tissue specificity
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. -
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
Post-translational
modificationsAutophosphorylated. -
Cellular localization
Membrane. - Information by UniProt
-
Database links
- Entrez Gene: 91 Human
- Omim: 601300 Human
- SwissProt: P36896 Human
- Unigene: 438918 Human
-
Form
There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3. -
Alternative names
- Activin A receptor type 1B antibody
- Activin A receptor type II like kinase 4 antibody
- Activin A type 1B receptor antibody
see all
Images
-
Anti-Activin A Receptor Type IB/ALK-4 antibody [MM0054-11A7] (ab78415) at 1/100 dilution + Human embryonic tissue lysate
Predicted band size: 57 kDa
Observed band size: 58 kDa why is the actual band size different from the predicted? -
ab78415 at 1/50 dilution, staining Activin A Receptor Type IB/ALK-4 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).
Datasheets and documents
-
Datasheet download
References (1)
ab78415 has been referenced in 1 publication.
- Tengroth L et al. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. Sci Rep 8:1561 (2018). PubMed: 29367682