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Overview
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Product nameAnti-Activin A Receptor Type IC antibody
See all Activin A Receptor Type IC primary antibodies -
DescriptionRabbit polyclonal to Activin A Receptor Type IC
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Specificityab111121 detects endogenous levels of total Activin A Receptor Type IC protein.
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Tested applicationsSuitable for: IHC-P, ICC/IFmore details
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Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
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Immunogen
Synthetic peptide derived from an internal sequence of Human Activin A Receptor Type IC.
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Positive control
- COS7 cells, Human brain tissue
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.88% Sodium chloride, 49.1% PBS
Note: PBS is without Mg2+ and Ca2+. -
Concentration information loading... -
PurityImmunogen affinity purified
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Purification notesab111121 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab111121 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. | |
| ICC/IF | 1/100 - 1/500. |
Target
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FunctionSerine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
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Tissue specificityPresent in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
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Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
Cellular localizationMembrane.
- Information by UniProt
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Database links
- Entrez Gene: 130399 Human
- Entrez Gene: 269275 Mouse
- Entrez Gene: 245921 Rat
- Omim: 608981 Human
- SwissProt: Q8NER5 Human
- SwissProt: Q8K348 Mouse
- SwissProt: P70539 Rat
- Unigene: 562901 Human
see all -
Alternative names
- Activin A receptor, type IC antibody
- Activin receptor like kinase 7 antibody
- Activin receptor type 1C precursor antibody
see all
Anti-Activin A Receptor Type IC antibody images
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Immunocytochemistry/ Immunofluorescence - Activin A Receptor Type IC antibody (ab111121)Immunofluorescence analysis of Activin A Receptor Type IC in COS7 cells, using ab111121 at a 1/100 dilution. The imge on the right is from cells treated with the synthesized peptide. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Activin A Receptor Type IC antibody (ab111121)ab111121, at a 1/50 dilution, staining Activin A Receptor Type IC in paraffin embedded Human brain tissue by Immunohistochemistry. The image on the right is from cells treated with the synthesized peptide.
References for Anti-Activin A Receptor Type IC antibody (ab111121)
ab111121 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"