Anti-Activin A Receptor Type IC antibody (ab111121)
- Datasheet
- Specific References (1)
- Protocols
Overview
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Product nameAnti-Activin A Receptor Type IC antibody
See all Activin A Receptor Type IC primary antibodies -
DescriptionRabbit polyclonal to Activin A Receptor Type IC
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Host speciesRabbit
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Specificityab111121 detects endogenous levels of total Activin A Receptor Type IC protein.
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Tested applicationsSuitable for: IHC-P, ICC/IFmore details
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Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
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Immunogen
Synthetic peptide derived from an internal sequence of Human Activin A Receptor Type IC.
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Positive control
- COS7 cells, Human brain tissue
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.88% Sodium chloride, 49.1% PBS
Note: PBS is without Mg2+ and Ca2+. -
Concentration information loading... -
PurityImmunogen affinity purified
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Purification notesab111121 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab111121 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. | |
| ICC/IF | 1/100 - 1/500. |
Target
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FunctionSerine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
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Tissue specificityPresent in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
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Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
Cellular localizationMembrane.
- Information by UniProt
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Database links
- Entrez Gene: 130399 Human
- Entrez Gene: 269275 Mouse
- Entrez Gene: 245921 Rat
- Omim: 608981 Human
- SwissProt: Q8NER5 Human
- SwissProt: Q8K348 Mouse
- SwissProt: P70539 Rat
- Unigene: 562901 Human
see all -
Alternative names
- Activin A receptor, type IC antibody
- Activin receptor like kinase 7 antibody
- Activin receptor type 1C precursor antibody
see all
Images
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Immunocytochemistry/ Immunofluorescence - Activin A Receptor Type IC antibody (ab111121)Immunofluorescence analysis of Activin A Receptor Type IC in COS7 cells, using ab111121 at a 1/100 dilution. The imge on the right is from cells treated with the synthesized peptide. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Activin A Receptor Type IC antibody (ab111121)ab111121, at a 1/50 dilution, staining Activin A Receptor Type IC in paraffin embedded Human brain tissue by Immunohistochemistry. The image on the right is from cells treated with the synthesized peptide.
References
This product has been referenced in:
- Tengroth L et al. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. Sci Rep 8:1561 (2018). Read more (PubMed: 29367682) »
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"