Anti-Activin A Receptor Type IC antibody (ab65088)

Overview

  • Product nameAnti-Activin A Receptor Type IC antibody
    See all Activin A Receptor Type IC primary antibodies
  • Description
    Rabbit polyclonal to Activin A Receptor Type IC
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human Activin A Receptor Type IC.

    (Peptide available as ab74349.)

  • Positive control
    • This antibody gave a positive signal in Human spleen tissue lysate. It also gave positive results in Human lung, ovary, placenta, heart, testis and kidney (data not shown).

Properties

Applications

Our Abpromise guarantee covers the use of ab65088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 55 kDa).

Target

  • FunctionSerine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
  • Tissue specificityPresent in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor, type IC antibody
    • Activin receptor like kinase 7 antibody
    • Activin receptor type 1C precursor antibody
    • Activin receptor type IC antibody
    • Activin receptor type-1C antibody
    • Activin receptor-like kinase 7 antibody
    • ACTR IC antibody
    • ACTR-IC antibody
    • ACTRIC antibody
    • ACV1C_HUMAN antibody
    • Acvr1c antibody
    • ACVRLK7 antibody
    • ALK 7 antibody
    • ALK-7 antibody
    • ALK7 antibody
    see all

Anti-Activin A Receptor Type IC antibody images

  • Anti-Activin A Receptor Type IC antibody (ab65088) at 2 µg/ml + Human spleen tissue lysate - total protein (ab29699) at 20 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size : 55 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)


    Exposure time : 30 seconds

References for Anti-Activin A Receptor Type IC antibody (ab65088)

ab65088 has not yet been referenced specifically in any publications.

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