Anti-Activin A Receptor Type IC antibody (ab67921)

Overview

  • Product name
    Anti-Activin A Receptor Type IC antibody
    See all Activin A Receptor Type IC primary antibodies
  • Description
    Mouse polyclonal to Activin A Receptor Type IC
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Activin A Receptor Type IC (NP_660302.1, 1 a.a. ~ 493 a.a) full-length human protein.

  • Positive control
    • ACVR1C transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 55 kDa.

Target

  • Function
    Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
  • Tissue specificity
    Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
  • Sequence similarities
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor, type IC antibody
    • Activin receptor like kinase 7 antibody
    • Activin receptor type 1C precursor antibody
    • Activin receptor type IC antibody
    • Activin receptor type-1C antibody
    • Activin receptor-like kinase 7 antibody
    • ACTR IC antibody
    • ACTR-IC antibody
    • ACTRIC antibody
    • ACV1C_HUMAN antibody
    • Acvr1c antibody
    • ACVRLK7 antibody
    • ALK 7 antibody
    • ALK-7 antibody
    • ALK7 antibody
    see all

Images

  • All lanes : Anti-Activin A Receptor Type IC antibody (ab67921) at 1/500 dilution

    Lane 1 : ACVR1C transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-mouse IgG (H&L)-HRP at 1/2000 dilution

    Predicted band size : 55 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)

References

ab67921 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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