Anti-Activin A Receptor Type IC antibody - Aminoterminal end (ab71539)

Overview

  • Product name
    Anti-Activin A Receptor Type IC antibody - Aminoterminal end
    See all Activin A Receptor Type IC primary antibodies
  • Description
    Rabbit polyclonal to Activin A Receptor Type IC - Aminoterminal end
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the N terminal region of human Activin A Receptor Type IC.

  • Positive control
    • IHC-P: Human hepatocarcinoma tissue sections. WB: HepG2, Hela cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab71539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
IHC-P
  • Application notes
    ELISA: 1/1000.
    IHC-P: 1/50 - 1/100.
    WB: 1/100 - 1/500. Detects bands of approximately 18, 37, 60 and 75 kDa (predicted molecular weight: 55 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
    • Tissue specificity
      Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
    • Sequence similarities
      Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 GS domain.
      Contains 1 protein kinase domain.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Activin A receptor, type IC antibody
      • Activin receptor like kinase 7 antibody
      • Activin receptor type 1C precursor antibody
      • Activin receptor type IC antibody
      • Activin receptor type-1C antibody
      • Activin receptor-like kinase 7 antibody
      • ACTR IC antibody
      • ACTR-IC antibody
      • ACTRIC antibody
      • ACV1C_HUMAN antibody
      • Acvr1c antibody
      • ACVRLK7 antibody
      • ALK 7 antibody
      • ALK-7 antibody
      • ALK7 antibody
      see all

    Images

    • All lanes : Anti-Activin A Receptor Type IC antibody - Aminoterminal end (ab71539) at 1/100 dilution

      Lane 1 : HepG2 cell line lysate
      Lane 2 : Hela cell line lysate

      Lysates/proteins at 12.5 µg per lane.


      Predicted band size : 55 kDa
      Observed band size : 60 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 18 kDa,37 kDa,75 kDa. We are unsure as to the identity of these extra bands.
    • Formalin-fixed and paraffin-embedded human hepatocarinoma tissue reacted with ab71539 at 1:50 dilution, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

    References

    ab71539 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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