Anti-Activin Receptor Type IA antibody (ab115301)


  • Product nameAnti-Activin Receptor Type IA antibody
    See all Activin Receptor Type IA primary antibodies
  • Description
    Goat polyclonal to Activin Receptor Type IA
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Goat, Horse, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 147-161 of Human Activin Receptor Type IA.

  • Positive control
    • Human Testis tissue; Human Umbilical Cord lysate



Our Abpromise guarantee covers the use of ab115301 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 57 kDa.
ELISA 1/128000.
IHC-P Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
  • Tissue specificityExpressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
  • Involvement in diseaseDefects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor type I antibody
    • Activin A receptor type II like kinase 2 antibody
    • Activin receptor type I antibody
    • Activin receptor type-1 antibody
    • Activin receptor-like kinase 2 antibody
    • ACTR-I antibody
    • ACTRI antibody
    • Acvr1 antibody
    • ACVR1_HUMAN antibody
    • ACVR1A antibody
    • ACVRLK2 antibody
    • ALK 2 antibody
    • ALK-2 antibody
    • ALK2 antibody
    • FOP antibody
    • Hydroxyalkyl protein kinase antibody
    • Serine/threonine-protein kinase receptor R1 antibody
    • SKR1 antibody
    • TGF-B superfamily receptor type I antibody
    • TGFB superfamily receptor type I antibody
    • TSR-I antibody
    • TSRI antibody
    see all

Anti-Activin Receptor Type IA antibody images

  • ab115301, at 4 µg/ml, staining Activin Receptor Type IA in formalin-fixed, paraffin-embedded Human Testis by Immunohistochemistry, using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-Activin Receptor Type IA antibody (ab115301) at 0.3 µg/ml + Human Umbilical Cord lysate (in RIPA buffer) at 35 µg
    developed using the ECL technique

    Predicted band size : 57 kDa

References for Anti-Activin Receptor Type IA antibody (ab115301)

ab115301 has not yet been referenced specifically in any publications.

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Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products. I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused...

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Thank you for your email. The antibody dilutions vary from antibody to antibody. For ab47086, the recommended dilution range is 3 - 5 µg/ml. For ab115301, the recommended dilution range is 0.3 - 1 µg/ml. But the optimal dilutions/concentrations should ...

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Thank you for contacting us. The WB protocol for ab115301 is as follows: Western blot protocol - The membrane is blocked in 3% (w/v) skimmed milk in TBS -T for 1 hr at room temperature with agitation (can be blocked overnight at 4°C without ...

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