Anti-Activin Receptor Type IA antibody (ab47086)

Overview

  • Product nameAnti-Activin Receptor Type IA antibody
    See all Activin Receptor Type IA primary antibodies
  • Description
    Rabbit polyclonal to Activin Receptor Type IA
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide, sequence taken from within amino acids 475-525 of human ACVR1.

  • Positive control
    • Mouse kidney lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab47086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 3 - 5 µg/ml. Detects a band of approximately 54 kDa (predicted molecular weight: 57 kDa). (In human kidney, additional bands are seen at approximately 27 and 14 kD.)

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
    • Tissue specificityExpressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
    • Involvement in diseaseDefects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
    • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 GS domain.
      Contains 1 protein kinase domain.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Activin A receptor type I antibody
      • Activin A receptor type II like kinase 2 antibody
      • Activin receptor type I antibody
      • Activin receptor type-1 antibody
      • Activin receptor-like kinase 2 antibody
      • ACTR-I antibody
      • ACTRI antibody
      • Acvr1 antibody
      • ACVR1_HUMAN antibody
      • ACVR1A antibody
      • ACVRLK2 antibody
      • ALK 2 antibody
      • ALK-2 antibody
      • ALK2 antibody
      • FOP antibody
      • Hydroxyalkyl protein kinase antibody
      • Serine/threonine-protein kinase receptor R1 antibody
      • SKR1 antibody
      • TGF-B superfamily receptor type I antibody
      • TGFB superfamily receptor type I antibody
      • TSR-I antibody
      • TSRI antibody
      see all

    Anti-Activin Receptor Type IA antibody images

    References for Anti-Activin Receptor Type IA antibody (ab47086)

    ab47086 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your email. The antibody dilutions vary from antibody to antibody. For ab47086, the recommended dilution range is 3 - 5 µg/ml. For ab115301, the recommended dilution range is 0.3 - 1 µg/ml. But the optimal dilutions/concentrations should ...

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    Thank you for contacting us. The WB protocol for ab47086 is as follows: 1. Equal amounts (about 10-50 μg/lane) of protein samples are resolved by SDS-PAGE and electro-blotted using a mini-gel transfer system onto a PVDF membrane using a current ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"